Health system weaknesses are a major impediment to achievement of the Sustainable Development Goals (SDGs) and other health targets. Globally, health systems strengthening has been recognised as critical for improvement of health services and subsequently health outcomes. This training curriculum seeks to provide both the trainers and trainees with a comprehensive approach to health system strengthening. Upon implementation, this training is expected to produce a critical mass of policy makers and practitioners who understand the tenets and principles of health systems and will contribute to overall health systems strengthening to improvement of health outcomes across Africa.